Mahidol University is widely recognized for producing medical and public-health professionals who drive the development of the public health system for the nation, and also for producing graduates in other fields for the global labor market. The University takes into vital consideration the well-being of its personnel by supporting welfare and benefits covering all services, including medical treatment, services, and other University facilities. Career progression is divided into two main tracks: academic staff and support staff. For the academic staff track, instructors and researchers are able to be promoted to higher levels, such as senior researcher level 1-4, assistant professor, associate professor, and professor. Support staff can be promoted to higher levels from senior professional level, expert level, and advisory level. Additional financial supports include Mahidol University provident funds, various grants, and performance evaluation linked to fair remuneration. Under good governance, performance evaluations are conducted two times each year for all levels. Mahidol University is playing a significant role during the COVID-19 pandemic by teaching and developing business skills for people who are affected. Due to the pandemic, supermarkets, companies, service providers, etc. have been unable to operate, and consequently the unemployment rate has increased. Therefore, Mahidol University has offered short-term online courses for Upskill and Reskill, such as trading and creating new careers, the fundamentals of branding, startup, business funding entrepreneurship, and innovation for seniors, tourism businesses and management services in the fourth industrial revolution (Industry 4.0 era), etc. These have helped to create opportunities to start online business channels to derive sustainable living incomes.